Smooth Muscle Specific Ablation of CXCL12 in Mice Downregulates CXCR7 Associated with Defective Coronary Arteries and Cardiac Hypertrophy

Smooth Muscle Specific Ablation of CXCL12 in Mice Downregulates CXCR7 Associated with Defective Coronary Arteries and Cardiac Hypertrophy

The chemokine CXCL12 plays a fundamental role in cardiovascular development, cell trafficking, and myocardial repair. Human genome-wide association studies even have identified novel loci downstream of the CXCL12 gene locus associated with coronary artery disease and myocardial infarction. Neverthel...

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Bibliographic Details
Main Authors: Santhosh Kumar Ghadge, Moritz Messner, Herbert Seiringer, Thomas Maurer, Simon Staggl, Tanja Zeller, Christian Müller, Daniela Börnigen, Wolfgang J. Weninger, Stefan H. Geyer, Sieghart Sopper, Anne Krogsdam, Gerhard Pölzl, Axel Bauer, Marc-Michael Zaruba
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
CXCL12
cardiac hypertrophy
fibrosis
remodeling
M2 macrophages
coronary artery
Online Access:https://www.mdpi.com/1422-0067/22/11/5908

Internet

https://www.mdpi.com/1422-0067/22/11/5908

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