Pilot Study on Quantitative Cervical Cord and Muscular MRI in Spinal Muscular Atrophy: Promising Biomarkers of Disease Evolution and Treatment?

Pilot Study on Quantitative Cervical Cord and Muscular MRI in Spinal Muscular Atrophy: Promising Biomarkers of Disease Evolution and Treatment?

Introduction: Nusinersen is a recent promising therapy approved for the treatment of spinal muscular atrophy (SMA), a rare disease characterized by the degeneration of alpha motor neurons (αMN) in the spinal cord (SC) leading to progressive muscle atrophy and dysfunction. Muscle and cervical SC quan...

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Bibliographic Details
Main Authors: Giovanni Savini, Carlo Asteggiano, Matteo Paoletti, Stefano Parravicini, Elena Pezzotti, Francesca Solazzo, Shaun I. Muzic, Francesco Santini, Xeni Deligianni, Alice Gardani, Giancarlo Germani, Lisa M. Farina, Niels Bergsland, Claudia A. M. Gandini Wheeler-Kingshott, Angela Berardinelli, Stefano Bastianello, Anna Pichiecchio
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Neurology
Subjects:
spinal muscular atrophy
muscle MRI
nusinersen (spinraza)
motor neuron degeneration
spinal cord atrophy and degeneration
muscle fat fraction
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2021.613834/full

Internet

https://www.frontiersin.org/articles/10.3389/fneur.2021.613834/full

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