Amyloid β Is Not the Major Factor Accounting for Impaired Adult Hippocampal Neurogenesis in Mice Overexpressing Amyloid Precursor Protein

Amyloid β Is Not the Major Factor Accounting for Impaired Adult Hippocampal Neurogenesis in Mice Overexpressing Amyloid Precursor Protein

Adult hippocampal neurogenesis was impaired in several Alzheimer's disease models overexpressing mutant human amyloid precursor protein (hAPP). However, the effects of wild-type hAPP on adult neurogenesis and whether the impaired adult hippocampal neurogenesis was caused by amyloid β (Aβ) or AP...

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Bibliographic Details
Main Authors: Hongyu Pan, Dongpi Wang, Xiaoqin Zhang, Dongming Zhou, Heng Zhang, Qi Qian, Xiao He, Zhaoling Liu, Yunjin Liu, Tingting Zheng, Ling Zhang, Mingkai Wang, Binggui Sun
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Stem Cell Reports
Subjects:
Alzheimer’s disease
hAPP
amyloid β
adult neurogenesis
hippocampus
mouse
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671116301862

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http://www.sciencedirect.com/science/article/pii/S2213671116301862

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