Macrophage-Specific NF-κB Activation Dynamics Can Segregate Inflammatory Bowel Disease Patients

Macrophage-Specific NF-κB Activation Dynamics Can Segregate Inflammatory Bowel Disease Patients

The heterogeneous nature of inflammatory bowel disease (IBD) presents challenges, particularly when choosing therapy. Activation of the NF-κB transcription factor is a highly regulated, dynamic event in IBD pathogenesis. Using a lentivirus approach, NF-κB-regulated luciferase was expressed in patien...

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Bibliographic Details
Main Authors: Stamatia Papoutsopoulou, Michael D. Burkitt, François Bergey, Hazel England, Rachael Hough, Lorraine Schmidt, David G. Spiller, Michael H. R. White, Pawel Paszek, Dean A. Jackson, Vitor A. P. Martins Dos Santos, Gernot Sellge, D. Mark Pritchard, Barry J. Campbell, Werner Müller, Chris S. Probert
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Immunology
Subjects:
inflammatory bowel disease
NF-κB
macrophages
cytokines
Crohn's disease
ulcerative colitis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02168/full

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