HEMNMA-3D: Cryo Electron Tomography Method Based on Normal Mode Analysis to Study Continuous Conformational Variability of Macromolecular Complexes

HEMNMA-3D: Cryo Electron Tomography Method Based on Normal Mode Analysis to Study Continuous Conformational Variability of Macromolecular Complexes

Cryogenic electron tomography (cryo-ET) allows structural determination of biomolecules in their native environment (in situ). Its potential of providing information on the dynamics of macromolecular complexes in cells is still largely unexploited, due to the challenges of the data analysis. The cro...

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Bibliographic Details
Main Authors: Mohamad Harastani, Mikhail Eltsov, Amélie Leforestier, Slavica Jonic
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Molecular Biosciences
Subjects:
cryo electron tomography
continuous conformational changes
flexible-reference alignment
normal mode analysis
nucleosomes in situ
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.663121/full

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https://www.frontiersin.org/articles/10.3389/fmolb.2021.663121/full

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