Generation of induced pluripotent stem cells (iPSCs) from an Alzheimer's disease patient carrying a M146I mutation in PSEN1

Generation of induced pluripotent stem cells (iPSCs) from an Alzheimer's disease patient carrying a M146I mutation in PSEN1

Skin fibroblasts were obtained from a 46-year-old symptomatic man carrying a M146I mutation in the presenilin 1 gene (PSEN1), responsible for causing Alzheimer's disease (AD). Induced pluripotent stem cells (iPSCs) were derived via transfection with episomal vectors carrying hOCT4, hSOX2, hKLF2...

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Bibliographic Details
Main Authors: Tong Li, Carlota Pires, Troels T. Nielsen, Gunhild Waldemar, Lena E. Hjermind, Jørgen E. Nielsen, Andras Dinnyes, Bjørn Holst, Poul Hyttel, Kristine K. Freude
Format: Article
Language:English
Published: Elsevier 2016-03-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506116000118

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http://www.sciencedirect.com/science/article/pii/S1873506116000118

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