Gene expression dysregulation domains are not a specific feature of Down syndrome

Gene expression dysregulation domains are not a specific feature of Down syndrome

Gene expression dysregulation domains (GEDDs) have been reported in Down syndrome (DS) cells, where changes in gene expression are clustered. Here the authors find that, while GEDDs are present in DS cells and in the Dp1Tyb mouse model of DS, GEDDs do not depend on the DS genotype and occur whenever...

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Bibliographic Details
Main Authors: Helena Ahlfors, Nneka Anyanwu, Edvinas Pakanavicius, Natalia Dinischiotu, Eva Lana-Elola, Sheona Watson-Scales, Justin Tosh, Frances Wiseman, James Briscoe, Karen Page, Elizabeth M. C. Fisher, Victor L. J. Tybulewicz
Format: Article
Language:English
Published: Nature Publishing Group 2019-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10129-9

Internet

https://doi.org/10.1038/s41467-019-10129-9

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