Pharmacological Evaluation and Preparation of Nonsteroidal Anti-Inflammatory Drugs Containing an N-Acyl Hydrazone Subunit

Pharmacological Evaluation and Preparation of Nonsteroidal Anti-Inflammatory Drugs Containing an N-Acyl Hydrazone Subunit

A series of anti-inflammatory derivatives containing an N-acyl hydrazone subunit (4a–e) were synthesized and characterized. Docking studies were performed that suggest that compounds 4a–e bind to cyclooxygenase (COX)-1 and COX-2 isoforms, but with higher affinity for COX-2. The compounds display sim...

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Bibliographic Details
Main Authors: Thais Regina Ferreira de Melo, Rafael Consolin Chelucci, Maria Elisa Lopes Pires, Luiz Antonio Dutra, Karina Pereira Barbieri, Priscila Longhin Bosquesi, Gustavo Henrique Goulart Trossini, Man Chin Chung, Jean Leandro dos Santos
Format: Article
Language:English
Published: MDPI AG 2014-04-01
Series:International Journal of Molecular Sciences
Subjects:
anti-inflammatory
analgesic
hydrazone
molecular hybridization
non-steroidal anti-inflammatory
NSAID
docking
molecular modeling
COX
Online Access:http://www.mdpi.com/1422-0067/15/4/5821

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http://www.mdpi.com/1422-0067/15/4/5821

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