Early Functional Impairment in Experimental Glaucoma Is Accompanied by Disruption of the GABAergic System and Inceptive Neuroinflammation

Early Functional Impairment in Experimental Glaucoma Is Accompanied by Disruption of the GABAergic System and Inceptive Neuroinflammation

Glaucoma is a leading cause of irreversible blindness worldwide, and increased intraocular pressure (IOP) is a major risk factor. We aimed to determine if early functional and molecular differences in the glaucomatous retina manifest before significant retinal ganglion cell (RGC) loss is apparent. A...

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Bibliographic Details
Main Authors: Oliver W. Gramlich, Cheyanne R. Godwin, David Wadkins, Benjamin W. Elwood, Markus H. Kuehn
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
glaucoma
myocilin
pattern electroretinography
γ-aminobutyric acid (GABA)
neuroinflammation
retinal ganglion cell loss
Online Access:https://www.mdpi.com/1422-0067/22/14/7581

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https://www.mdpi.com/1422-0067/22/14/7581

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