Targeted test evaluation: a framework for designing diagnostic accuracy studies with clear study hypotheses

Abstract Most randomized controlled trials evaluating medical interventions have a pre-specified hypothesis, which is statistically tested against the null hypothesis of no effect. In diagnostic accuracy studies, study hypotheses are rarely pre-defined and sample size calculations are usually not pe...

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Bibliographic Details
Main Authors: Daniël A. Korevaar, Gowri Gopalakrishna, Jérémie F. Cohen, Patrick M. Bossuyt
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Diagnostic and Prognostic Research
Online Access:https://doi.org/10.1186/s41512-019-0069-2