Unsupervised Idealization of Ion Channel Recordings by Minimum Description Length: Application to Human PIEZO1-Channels

Unsupervised Idealization of Ion Channel Recordings by Minimum Description Length: Application to Human PIEZO1-Channels

Researchers can investigate the mechanistic and molecular basis of many physiological phenomena in cells by analyzing the fundamental properties of single ion channels. These analyses entail recording single channel currents and measuring current amplitudes and transition rates between conductance s...

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Bibliographic Details
Main Authors: Jakob K. Dreyer, Radhakrishnan Gnanasambandam, Morten S. Nielsen, Christopher Nicolai, Frederick Sachs, Johannes P. Hofgaard
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-04-01
Series:Frontiers in Neuroinformatics
Subjects:
ion channel gating
idealization
Markov models
minimum description length
mechanoreceptors
Online Access:http://journal.frontiersin.org/article/10.3389/fninf.2017.00031/full

Internet

http://journal.frontiersin.org/article/10.3389/fninf.2017.00031/full

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