The fibronectin synergy site re-enforces cell adhesion and mediates a crosstalk between integrin classes

The fibronectin synergy site re-enforces cell adhesion and mediates a crosstalk between integrin classes

Fibronectin (FN), a major extracellular matrix component, enables integrin-mediated cell adhesion via binding of α5β1, αIIbβ3 and αv-class integrins to an RGD-motif. An additional linkage for α5 and αIIb is the synergy site located in close proximity to the RGD motif. We report that mice with a dysf...

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Bibliographic Details
Main Authors: Maria Benito-Jardón, Sarah Klapproth, Irene Gimeno-LLuch, Tobias Petzold, Mitasha Bharadwaj, Daniel J Müller, Gabriele Zuchtriegel, Christoph A Reichel, Mercedes Costell
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-01-01
Series:eLife
Subjects:
integrins
fibronectin
mechanosignaling
extracellular matrix
cell adhesion
Online Access:https://elifesciences.org/articles/22264

Internet

https://elifesciences.org/articles/22264

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