A Putative Mechanism of Age-Related Synaptic Dysfunction Based on the Impact of IGF-1 Receptor Signaling on Synaptic CaMKIIα Phosphorylation

A Putative Mechanism of Age-Related Synaptic Dysfunction Based on the Impact of IGF-1 Receptor Signaling on Synaptic CaMKIIα Phosphorylation

Insulin-like growth factor 1 receptor (IGF-1R) signaling regulates the activity and phosphorylation of downstream kinases linked to inflammation, neurodevelopment, aging and synaptic function. In addition to the control of Ca2+ currents, IGF-1R signaling modulates the activity of calcium-calmodulin-...

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Bibliographic Details
Main Authors: Olalekan M. Ogundele, Joaquin Pardo, Joseph Francis, Rodolfo G. Goya, Charles C. Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Neuroanatomy
Subjects:
IGF-1/IGF-1R
aging
CaMKIIα
MAPK/ErK
KCa2.2
Online Access:http://journal.frontiersin.org/article/10.3389/fnana.2018.00035/full

Internet

http://journal.frontiersin.org/article/10.3389/fnana.2018.00035/full

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