Comparison of the expression and toxicity of AAV2/9 carrying the human A53T α-synuclein gene in presence or absence of WPRE

Comparison of the expression and toxicity of AAV2/9 carrying the human A53T α-synuclein gene in presence or absence of WPRE

Woodchuck Hepatitis Virus Post-transcriptional Regulatory Element (WPRE) is thought to enhance transgene expression of target genes delivered by adeno-associated viral (AAV) vectors. This study assessed the protein expression of α-synuclein, phosphorylated α-synuclein at Serine 129, extent of nigros...

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Bibliographic Details
Main Authors: Xiuping Sun, Xuan Yu, Ling Zhang, Wenjie Zhao, Manshi Wang, Yu Zhang, Xianglei Li, Ran Gao, Ludivine S. Breger, Sandra Dovero, Gregory Porras, Pierre-Olivier Fernagut, Benjamin Dehay, Erwan Bezard, Chuan Qin
Format: Article
Language:English
Published: Elsevier 2021-02-01
Series:Heliyon
Subjects:
Parkinson's disease
Synucleinopathy
Woodchuck hepatitis virus post-transcriptional regulatory element
Mouse
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844021004072

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http://www.sciencedirect.com/science/article/pii/S2405844021004072

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