Tau Exon 10 Inclusion by PrP<sup>C</sup> through Downregulating GSK3β Activity

Tau Exon 10 Inclusion by PrP<sup>C</sup> through Downregulating GSK3β Activity

Tau protein is largely responsible for tauopathies, including Alzheimer’s disease (AD), where it accumulates in the brain as insoluble aggregates. Tau mRNA is regulated by alternative splicing, and inclusion or exclusion of exon 10 gives rise to the 3R and 4R isoforms respectively, whose balance is...

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Bibliographic Details
Main Authors: Laia Lidón, Laura Llaó-Hierro, Mario Nuvolone, Adriano Aguzzi, Jesús Ávila, Isidro Ferrer, José Antonio del Río, Rosalina Gavín
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
cellular prion protein
GSK3β
microtubule-associated protein tau
alternative splicing
Alzheimer’s disease
tauopathies
Online Access:https://www.mdpi.com/1422-0067/22/10/5370

Internet

https://www.mdpi.com/1422-0067/22/10/5370

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