The effects of Di-(2-ethylhexyl)-phthalate exposure on fertilization and embryonic development in vitro and testicular genomic mutation in vivo.

The present study was undertaken to determine the reproductive hazards of Di-(2-ethylhexyl)-phthalate (DEHP) on mouse spermatozoa and embryos in vitro and genomic changes in vivo. Direct low-level DEHP exposure (1 μg/ml) on spermatozoa and embryos was investigated by in vitro fertilization (IVF) pro...

Full description

Bibliographic Details
Main Authors: Xue-Feng Huang, Yan Li, Yi-Hua Gu, Miao Liu, Yan Xu, Yao Yuan, Fei Sun, Hui-Qin Zhang, Hui-Juan Shi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3511574?pdf=render