The adeno-associated virus rh10 vector is an effective gene transfer system for chronic spinal cord injury

Abstract Treatment options for chronic spinal cord injury (SCI) remain limited due to unfavourable changes in the microenvironment. Gene therapy can overcome these barriers through continuous delivery of therapeutic gene products to the target tissue. In particular, adeno-associated virus (AAV) vect...

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Bibliographic Details
Main Authors: Yutaka Hoshino, Kenji Nishide, Narihito Nagoshi, Shinsuke Shibata, Nobuko Moritoki, Kota Kojima, Osahiko Tsuji, Morio Matsumoto, Jun Kohyama, Masaya Nakamura, Hideyuki Okano
Format: Article
Language:English
Published: Nature Publishing Group 2019-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-019-46069-z