Synthesis of tetrahydropyrrolothiazoles through one-pot and four-component N,S-acetalation and decarboxylative [3+2] cycloaddition

A four-component and one-pot synthesis involving N,S-acetalation of aldehydes with cysteine followed by the reaction with second aldehydes for decarboxylative [3 ​+ ​2] cycloaddition with maleimides is developed for stereoselective synthesis of tetrahydropyrrolothiazoles. High synthetic efficiency,...

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Bibliographic Details
Main Authors: Xiaoming Ma, Weiqi Qiu, Li Liu, Xiaofeng Zhang, JohnMark Awad, Jason Evans, Wei Zhang
Format: Article
Language:English
Published: KeAi Communications Co. Ltd. 2021-02-01
Series:Green Synthesis and Catalysis
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2666554920300466