Extracellular Guanosine 5′-Triphosphate Induces Human Muscle Satellite Cells to Release Exosomes Stuffed With Guanosine

Extracellular Guanosine 5′-Triphosphate Induces Human Muscle Satellite Cells to Release Exosomes Stuffed With Guanosine

The extracellular guanosine 5′-triphosphate, GTP, has been demonstrated to be an enhancer of myogenic cell differentiation in a murine cell line, not yet in human muscle cells. Our hypothesis was that GTP could influence also human skeletal muscle regeneration, specifically in the first phases. We t...

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Bibliographic Details
Main Authors: Tiziana Pietrangelo, Ester S. Di Filippo, Marcello Locatelli, Francesco Piacenza, Marco Farina, Eleonora Pavoni, Andrea Di Donato, Denise Innosa, Mauro Provinciali, Stefania Fulle
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Pharmacology
Subjects:
satellite cells
guanosine
guanosine 5′-triphosphate
myomiRNA
exosomes
skeletal muscle regeneration
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00152/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2018.00152/full

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