Structure-Function Analysis of the Non-Muscle Myosin Light Chain Kinase (nmMLCK) Isoform by NMR Spectroscopy and Molecular Modeling: Influence of MYLK Variants.

Structure-Function Analysis of the Non-Muscle Myosin Light Chain Kinase (nmMLCK) Isoform by NMR Spectroscopy and Molecular Modeling: Influence of MYLK Variants.

The MYLK gene encodes the multifunctional enzyme, myosin light chain kinase (MLCK), involved in isoform-specific non-muscle and smooth muscle contraction and regulation of vascular permeability during inflammation. Three MYLK SNPs (P21H, S147P, V261A) alter the N-terminal amino acid sequence of the...

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Bibliographic Details
Main Authors: Kui Shen, Benjamin Ramirez, Brandon Mapes, Grace R Shen, Vijay Gokhale, Mary E Brown, Bernard Santarsiero, Yoshitaka Ishii, Steven M Dudek, Ting Wang, Joe G N Garcia
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4482139?pdf=render

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http://europepmc.org/articles/PMC4482139?pdf=render

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