Systemic and intrathecal baclofen produce bladder antinociception in rats

Abstract Background Baclofen, a clinically available GABAB receptor agonist, produces non-opioid analgesia in multiple models of pain but has not been tested for effects on bladder nociception. Methods A series of experiments examined the effects of systemic and spinally administered baclofen on bla...

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Bibliographic Details
Main Authors: Timothy J. Ness, Alan Randich, Xin Su, Cary DeWitte, Keith Hildebrand
Format: Article
Language:English
Published: BMC 2021-10-01
Series:BMC Urology
Subjects:
Online Access:https://doi.org/10.1186/s12894-021-00899-0