Resveratrol Pretreatment Improved Heart Recovery Ability of Hyperglycemic Bone Marrow Stem Cells Transplantation in Diabetic Myocardial Infarction by Down-Regulating MicroRNA-34a

Resveratrol Pretreatment Improved Heart Recovery Ability of Hyperglycemic Bone Marrow Stem Cells Transplantation in Diabetic Myocardial Infarction by Down-Regulating MicroRNA-34a

AIM: To examine the effect of resveratrol (RSV) on bone marrow mesenchymal stem cells (BMSCs) under hyperglycemic conditions and on BMSCs transplantation in diabetic rats with myocardial infarction (MI).METHODS:In vitro, BMSCs were isolated from 3-week-old male Sprague Dawley (SD) rats and cultured...

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Bibliographic Details
Main Authors: Fengyun Zhang, Kun Wang, Fei Gao, Yongli Xuan, Xiaohong Liu, Zhuoqi Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pharmacology
Subjects:
resveratrol
microrna-34a
bone marrow-derived mesenchymal stem cells
diabetes mellitus
myocardial infarction
senescence
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.632375/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.632375/full

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