Genetic deletion of Sphk2 confers protection against Pseudomonas aeruginosa mediated differential expression of genes related to virulent infection and inflammation in mouse lung

Genetic deletion of Sphk2 confers protection against Pseudomonas aeruginosa mediated differential expression of genes related to virulent infection and inflammation in mouse lung

Abstract Background Pseudomonas aeruginosa (PA) is an opportunistic Gram-negative bacterium that causes serious life threatening and nosocomial infections including pneumonia. PA has the ability to alter host genome to facilitate its invasion, thus increasing the virulence of the organism. Sphingosi...

Full description

Bibliographic Details
Main Authors: David L. Ebenezer, Panfeng Fu, Yashaswin Krishnan, Mark Maienschein-Cline, Hong Hu, Segun Jung, Ravi Madduri, Zarema Arbieva, Anantha Harijith, Viswanathan Natarajan
Format: Article
Language:English
Published: BMC 2019-12-01
Series:BMC Genomics
Subjects:
Pseudomonas aeruginosa
Pneumonia
Sphingosine kinase 2
Sphingolipids
Genomics, bacterial resistance
Online Access:https://doi.org/10.1186/s12864-019-6367-9

Internet

https://doi.org/10.1186/s12864-019-6367-9

Similar Items