A Murine Model of Mycobacterium kansasii Infection Reproducing Necrotic Lung Pathology Reveals Considerable Heterogeneity in Virulence of Clinical Isolates

A Murine Model of Mycobacterium kansasii Infection Reproducing Necrotic Lung Pathology Reveals Considerable Heterogeneity in Virulence of Clinical Isolates

Among non-tuberculous mycobacteria, Mycobacterium kansasii is one of the most pathogenic, able to cause pulmonary disease indistinguishable from tuberculosis in immunocompetent susceptible adults. The lack of animal models that reproduce human-like lung disease, associated with the necrotic lung pat...

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Bibliographic Details
Main Authors: Vinicius O. Mussi, Thatiana L. B. V. Simão, Fabrício M. Almeida, Edson Machado, Luciana D. de Carvalho, Sanderson D. Calixto, Guilherme A. M. Sales, Eulógio C. Q. Carvalho, Sidra E. G. Vasconcellos, Marcos Catanho, Philip N. Suffys, Elena B. Lasunskaia
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Microbiology
Subjects:
virulence
animal models
pulmonary disease
clinical isolates
Mycobacterium kansasii
nontuberculous mycobacteria
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.718477/full

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https://www.frontiersin.org/articles/10.3389/fmicb.2021.718477/full

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