Sodium tanshinone IIA sulfonate ameliorates hepatic steatosis by inhibiting lipogenesis and inflammation
Non-alcoholic fatty liver disease (NAFLD) is becoming an epidemic disease in adults and children worldwide. Importantly, there are currently no approved treatments available for NAFLD. This study aims to investigate the potential applications of sodium tanshinone IIA sulfonate (STS) on improving the...
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doaj-d5d1f980eefd4833b64310bb64a98aeb2021-05-20T07:36:51ZengElsevierBiomedicine & Pharmacotherapy0753-33222019-03-011116875Sodium tanshinone IIA sulfonate ameliorates hepatic steatosis by inhibiting lipogenesis and inflammationXiao-Xiao Li0Xin-Yi Lu1Shi-Jie Zhang2Amy P. Chiu3Lilian H. Lo4David A. Largaespada5Qu-Bo Chen6Vincent W. Keng7The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen, China; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong KongBiological Resource Centre, Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, ChinaThe Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen, China; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong; Department of Neurology, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaThe Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen, China; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong KongThe Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen, China; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong KongDepartment of Pediatrics, Masonic Cancer Center and Center for Genome Engineering, University of Minnesota, Minneapolis, MN, USABiological Resource Centre, Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China; Corresponding authors.The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen, China; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong; Corresponding authors.Non-alcoholic fatty liver disease (NAFLD) is becoming an epidemic disease in adults and children worldwide. Importantly, there are currently no approved treatments available for NAFLD. This study aims to investigate the potential applications of sodium tanshinone IIA sulfonate (STS) on improving the NAFLD condition using both in vitro and in vivo approaches. The results showed that STS markedly inhibited lipid accumulation in oleic acid (OA) and palmitic acid (PA) treated HepG2 and primary immortalized human hepatic (PIH) cells. STS suppressed lipogenesis by inhibiting expression of sterol regulatory element binding transcription factor 1 (SREBF1), fatty acid synthase (FASN) and stearoyl-CoA desaturase (SCD). In addition, STS reduced inflammation in cells treated with OA-PA, shown by decreased transcriptional levels of tumor necrosis factor (TNF), transforming growth factor beta 1 (TGFB1) and interleukin 1 beta (IL1B). Consistently, protective effects on hepatic steatosis in db/db mice were observed after STS administration, demonstrated by decreased lipid accumulation in mouse hepatocytes. This protective effect might be associated with STS induced activation of sirtuin 1 (SIRT1)/protein kinase AMP-activated catalytic subunit alpha 1 (PRKAA1) pathways. Our findings suggest a potential therapeutic role for STS in the treatment of NAFLD.http://www.sciencedirect.com/science/article/pii/S0753332218376376NAFLDSodium tanshinone IIA sulfonateSIRT1PRKAA1 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xiao-Xiao Li Xin-Yi Lu Shi-Jie Zhang Amy P. Chiu Lilian H. Lo David A. Largaespada Qu-Bo Chen Vincent W. Keng |
spellingShingle |
Xiao-Xiao Li Xin-Yi Lu Shi-Jie Zhang Amy P. Chiu Lilian H. Lo David A. Largaespada Qu-Bo Chen Vincent W. Keng Sodium tanshinone IIA sulfonate ameliorates hepatic steatosis by inhibiting lipogenesis and inflammation Biomedicine & Pharmacotherapy NAFLD Sodium tanshinone IIA sulfonate SIRT1 PRKAA1 |
author_facet |
Xiao-Xiao Li Xin-Yi Lu Shi-Jie Zhang Amy P. Chiu Lilian H. Lo David A. Largaespada Qu-Bo Chen Vincent W. Keng |
author_sort |
Xiao-Xiao Li |
title |
Sodium tanshinone IIA sulfonate ameliorates hepatic steatosis by inhibiting lipogenesis and inflammation |
title_short |
Sodium tanshinone IIA sulfonate ameliorates hepatic steatosis by inhibiting lipogenesis and inflammation |
title_full |
Sodium tanshinone IIA sulfonate ameliorates hepatic steatosis by inhibiting lipogenesis and inflammation |
title_fullStr |
Sodium tanshinone IIA sulfonate ameliorates hepatic steatosis by inhibiting lipogenesis and inflammation |
title_full_unstemmed |
Sodium tanshinone IIA sulfonate ameliorates hepatic steatosis by inhibiting lipogenesis and inflammation |
title_sort |
sodium tanshinone iia sulfonate ameliorates hepatic steatosis by inhibiting lipogenesis and inflammation |
publisher |
Elsevier |
series |
Biomedicine & Pharmacotherapy |
issn |
0753-3322 |
publishDate |
2019-03-01 |
description |
Non-alcoholic fatty liver disease (NAFLD) is becoming an epidemic disease in adults and children worldwide. Importantly, there are currently no approved treatments available for NAFLD. This study aims to investigate the potential applications of sodium tanshinone IIA sulfonate (STS) on improving the NAFLD condition using both in vitro and in vivo approaches. The results showed that STS markedly inhibited lipid accumulation in oleic acid (OA) and palmitic acid (PA) treated HepG2 and primary immortalized human hepatic (PIH) cells. STS suppressed lipogenesis by inhibiting expression of sterol regulatory element binding transcription factor 1 (SREBF1), fatty acid synthase (FASN) and stearoyl-CoA desaturase (SCD). In addition, STS reduced inflammation in cells treated with OA-PA, shown by decreased transcriptional levels of tumor necrosis factor (TNF), transforming growth factor beta 1 (TGFB1) and interleukin 1 beta (IL1B). Consistently, protective effects on hepatic steatosis in db/db mice were observed after STS administration, demonstrated by decreased lipid accumulation in mouse hepatocytes. This protective effect might be associated with STS induced activation of sirtuin 1 (SIRT1)/protein kinase AMP-activated catalytic subunit alpha 1 (PRKAA1) pathways. Our findings suggest a potential therapeutic role for STS in the treatment of NAFLD. |
topic |
NAFLD Sodium tanshinone IIA sulfonate SIRT1 PRKAA1 |
url |
http://www.sciencedirect.com/science/article/pii/S0753332218376376 |
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