Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis

Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis

Circular RNAs (circRNAs) are non-coding RNAs generated from pre-mRNAs of coding genes by the splicing machinery whose function in the heart is poorly understood. Here the authors show that AAV-mediated delivery of the circRNA circFndc3b prevents cardiomyocyte apoptosis, enhances angiogenesis, and at...

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Bibliographic Details
Main Authors: Venkata Naga Srikanth Garikipati, Suresh Kumar Verma, Zhongjian Cheng, Dongming Liang, May M. Truongcao, Maria Cimini, Yujia Yue, Grace Huang, Chunlin Wang, Cindy Benedict, Yan Tang, Vandana Mallaredy, Jessica Ibetti, Laurel Grisanti, Sarah M. Schumacher, Erhe Gao, Sudarsan Rajan, Jeremy E. Wilusz, David Goukassian, Steven R. Houser, Walter J. Koch, Raj Kishore
Format: Article
Language:English
Published: Nature Publishing Group 2019-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11777-7

Internet

https://doi.org/10.1038/s41467-019-11777-7

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