Human Adipose Tissue-Derived Mesenchymal Stem Cells Attenuate Atopic Dermatitis by Regulating the Expression of MIP-2, miR-122a-SOCS1 Axis, and Th1/Th2 Responses

Human Adipose Tissue-Derived Mesenchymal Stem Cells Attenuate Atopic Dermatitis by Regulating the Expression of MIP-2, miR-122a-SOCS1 Axis, and Th1/Th2 Responses

The objective of this study was to investigate the effect of human adipose tissue-derived mesenchymal stem cells (AdMSCs) on atopic dermatitis (AD) in the BALB/c mouse model. The AdMSCs attenuated clinical symptoms associated with AD, decreased numbers of degranulated mast cells (MCs), IgE level, am...

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Bibliographic Details
Main Authors: Misun Kim, Sung-Hoon Lee, Youngmi Kim, Yoojung Kwon, Yeongseo Park, Hong-Ki Lee, Hyun Suk Jung, Dooil Jeoung
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Pharmacology
Subjects:
adipose tissue-derived stem cells
atopic dermatitis
targets of stem cells
cellular interactions
MIP-2
miR-122a-5p
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01175/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01175/full

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