Generation of an immortalized astrocytic cell line from Abcd1-deficient H-2KbtsA58 mice to facilitate the study of the role of astrocytes in X-linked adrenoleukodystrophy

Generation of an immortalized astrocytic cell line from Abcd1-deficient H-2KbtsA58 mice to facilitate the study of the role of astrocytes in X-linked adrenoleukodystrophy

X-linked adrenoleukodystrophy (X-ALD) is an inherited metabolic disease characterized by inflammatory demyelination, and activated astrocytes as well as microglia are thought to be involved in its pathogenesis. Conditionally immortalized astrocytic cell clones were prepared from wild-type or Abcd1-d...

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Bibliographic Details
Main Authors: Masashi Morita, Ai Toida, Yuki Horiuchi, Shiro Watanabe, Masakiyo Sasahara, Kosuke Kawaguchi, Takanori So, Tsuneo Imanaka
Format: Article
Language:English
Published: Elsevier 2021-02-01
Series:Heliyon
Subjects:
Abcd1
Astrocyte
Immortalized cell
X-linked adrenoleukodystrophy
Peroxisome
Very long chain fatty acid
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844021003339

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http://www.sciencedirect.com/science/article/pii/S2405844021003339

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