Structures of Trypanosoma brucei methionyl-tRNA synthetase with urea-based inhibitors provide guidance for drug design against sleeping sickness.

Structures of Trypanosoma brucei methionyl-tRNA synthetase with urea-based inhibitors provide guidance for drug design against sleeping sickness.

Methionyl-tRNA synthetase of Trypanosoma brucei (TbMetRS) is an important target in the development of new antitrypanosomal drugs. The enzyme is essential, highly flexible and displaying a large degree of changes in protein domains and binding pockets in the presence of substrate, product and inhibi...

Full description

Bibliographic Details
Main Authors: Cho Yeow Koh, Jessica E Kim, Allan B Wetzel, Will J de van der Schueren, Sayaka Shibata, Ranae M Ranade, Jiyun Liu, Zhongsheng Zhang, J Robert Gillespie, Frederick S Buckner, Christophe L M J Verlinde, Erkang Fan, Wim G J Hol
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-04-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC3990509?pdf=render

Internet

http://europepmc.org/articles/PMC3990509?pdf=render

Similar Items