RADAR: annotation and prioritization of variants in the post-transcriptional regulome of RNA-binding proteins

RADAR: annotation and prioritization of variants in the post-transcriptional regulome of RNA-binding proteins

Abstract RNA-binding proteins (RBPs) play key roles in post-transcriptional regulation and disease. Their binding sites cover more of the genome than coding exons; nevertheless, most noncoding variant prioritization methods only focus on transcriptional regulation. Here, we integrate the portfolio o...

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Bibliographic Details
Main Authors: Jing Zhang, Jason Liu, Donghoon Lee, Jo-Jo Feng, Lucas Lochovsky, Shaoke Lou, Michael Rutenberg-Schoenberg, Mark Gerstein
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Genome Biology
Subjects:
RNA-binding protein
Post-transcriptional regulation
Variant prioritization
Variant functional impact
Online Access:http://link.springer.com/article/10.1186/s13059-020-01979-4

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http://link.springer.com/article/10.1186/s13059-020-01979-4

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