Development and validation of a variant detection workflow for BRCA1 and BRCA2 genes and its clinical application based on the Ion Torrent technology

Development and validation of a variant detection workflow for BRCA1 and BRCA2 genes and its clinical application based on the Ion Torrent technology

Abstract Background Breast cancer is the most common among women worldwide, and ovarian cancer is the most difficult gynecological tumor to diagnose and with the lowest chance of cure. Mutations in BRCA1 and BRCA2 genes increase the risk of ovarian cancer by 60% and breast cancer by up to 80% in wom...

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Bibliographic Details
Main Authors: Ana Lígia Buzolin, Caroline Mônaco Moreira, Patricia Rossi Sacramento, Andre Yuji Oku, Alexandre Ricardo dos Santos Fornari, David Santos Marco Antonio, Caio Robledo D Angioli Costa Quaio, Wagner Rosa Baratela, Miguel Mitne-Neto
Format: Article
Language:English
Published: BMC 2017-06-01
Series:Human Genomics
Subjects:
Cancer
Breast
Ovarian
Ion Torrent
BRCA
Online Access:http://link.springer.com/article/10.1186/s40246-017-0110-x

Internet

http://link.springer.com/article/10.1186/s40246-017-0110-x

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