Defective Localization With Impaired Tumor Cytotoxicity Contributes to the Immune Escape of NK Cells in Pancreatic Cancer Patients

Defective Localization With Impaired Tumor Cytotoxicity Contributes to the Immune Escape of NK Cells in Pancreatic Cancer Patients

Tumor-infiltrating lymphocytes (TILs), found in patients with advanced pancreatic ductal adenocarcinoma (PDAC), are shown to correlate with overall survival (OS) rate. Although majority of TILs consist of CD8+/CD4+ T cells, the presence of NK cells and their role in the pathogenesis of PDAC remains...

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Bibliographic Details
Main Authors: Seon Ah Lim, Jungwon Kim, Seunghyun Jeon, Min Hwa Shin, Joonha Kwon, Tae-Jin Kim, Kyungtaek Im, Youngmin Han, Wooil Kwon, Sun-Whe Kim, Cassian Yee, Seong-Jin Kim, Jin-Young Jang, Kyung-Mi Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Immunology
Subjects:
pancreatic cancer
cancer immunobiology
cellular immunology
immunotherapy
chemokines
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00496/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00496/full

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