The E3 Ubiquitin Ligase HectD1 Suppresses EMT and Metastasis by Targeting the +TIP ACF7 for Degradation

The E3 Ubiquitin Ligase HectD1 Suppresses EMT and Metastasis by Targeting the +TIP ACF7 for Degradation

Cancer cells exploit the epithelial-to-mesenchymal transition (EMT) program to become metastatic. Cytoskeletal regulators are required in mesenchymal cells where they promote EMT and EMT-induced migration. In a search for regulators of metastasis, we conducted shRNA screens targeting the microtubule...

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Bibliographic Details
Main Authors: Stéphanie Duhamel, Marie-Anne Goyette, Marie-Pier Thibault, Dominic Filion, Louis Gaboury, Jean-François Côté
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Cell Reports
Subjects:
HectD1
ACF7
ubiquitinylation
epithelial-to-mesenchymal transition
EMT
microtubule plus-end tracking proteins
migration
invasion
breast cancer
metastasis
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717319332

Internet

http://www.sciencedirect.com/science/article/pii/S2211124717319332

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