The Lifespan and Turnover of Microglia in the Human Brain

The hematopoietic system seeds the CNS with microglial progenitor cells during the fetal period, but the subsequent cell generation dynamics and maintenance of this population have been poorly understood. We report that microglia, unlike most other hematopoietic lineages, renew slowly at a median ra...

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Bibliographic Details
Main Authors: Pedro Réu, Azadeh Khosravi, Samuel Bernard, Jeff E. Mold, Mehran Salehpour, Kanar Alkass, Shira Perl, John Tisdale, Göran Possnert, Henrik Druid, Jonas Frisén
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Cell Reports
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717309439