Gender Differences in Global but Not Targeted Demethylation in iPSC Reprogramming

Gender Differences in Global but Not Targeted Demethylation in iPSC Reprogramming

Global DNA demethylation is an integral part of reprogramming processes in vivo and in vitro, but whether it occurs in the derivation of induced pluripotent stem cells (iPSCs) is not known. Here, we show that iPSC reprogramming involves both global and targeted demethylation, which are separable mec...

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Bibliographic Details
Main Authors: Inês Milagre, Thomas M. Stubbs, Michelle R. King, Julia Spindel, Fátima Santos, Felix Krueger, Martin Bachman, Anne Segonds-Pichon, Shankar Balasubramanian, Simon R. Andrews, Wendy Dean, Wolf Reik
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Cell Reports
Subjects:
reprogramming
iPSCs
DNA methylation
gender differences
AID
UHRF1
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717300268

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http://www.sciencedirect.com/science/article/pii/S2211124717300268

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