Detection of somatic TP53 mutations and 17p deletions in patients with chronic lymphocytic leukemia: a review of the current methods

Chronic lymphocytic leukemia is the most common hematologic malignancy among adults in Western countries. Several studies show that somatic mutations in the TP53 gene are present in up to 50% of patients with relapsed or refractory chronic lymphocytic leukemia. This study aims to review and compare...

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Bibliographic Details
Main Authors: Maria de Lourdes L.F. Chauffaille, Ilana Zalcberg, Wolney Gois Barreto, Israel Bendit
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Hematology, Transfusion and Cell Therapy
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2531137920300778