NADPH Oxidase-4 Driven Cardiac Macrophage Polarization Protects Against Myocardial Infarction–Induced Remodeling

NADPH Oxidase-4 Driven Cardiac Macrophage Polarization Protects Against Myocardial Infarction–Induced Remodeling

The reactive oxygen species–generating enzyme NADPH oxidase 4 (Nox4) is up-regulated in the heart after myocardial infarction (MI). Mice with cardiomyocyte-targeted Nox4 overexpression (TG) displayed increased macrophages in the heart at baseline, with skewing toward an M2 phenotype compared with wi...

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Bibliographic Details
Main Authors: Heloise Mongue-Din, PharmD, PhD, Ashish S. Patel, PhD, Yee H. Looi, PhD, David J. Grieve, PhD, Narayana Anilkumar, PhD, Alexander Sirker, PhD, Xuebin Dong, MD, PhD, Alison C. Brewer, PhD, Min Zhang, MD, PhD, Alberto Smith, PhD, Ajay M. Shah, MD
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:JACC: Basic to Translational Science
Subjects:
cardiac
infarction
ischemia
macrophage
NADPH oxidase
remodeling
Online Access:http://www.sciencedirect.com/science/article/pii/S2452302X17301547

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http://www.sciencedirect.com/science/article/pii/S2452302X17301547

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