CSN6 promotes melanoma proliferation and metastasis by controlling the UBR5-mediated ubiquitination and degradation of CDK9

CSN6 promotes melanoma proliferation and metastasis by controlling the UBR5-mediated ubiquitination and degradation of CDK9

Abstract As a critical subunit of the constitutive photomorphogenesis 9 (COP9) signalosome (CSN), CSN6 is upregulated in some human cancers and plays critical roles in tumorigenesis and progression, but its biological functions and molecular mechanisms in melanoma remain unknown. Our study showed th...

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Bibliographic Details
Main Authors: Yanli Zhang, Jianbing Hou, Shaomin Shi, Juan Du, Yudong Liu, Pan Huang, Qian Li, Lichao Liu, Huanrong Hu, Yacong Ji, Leiyang Guo, Yaqiong Shi, Yaling Liu, Hongjuan Cui
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-03398-0

Internet

https://doi.org/10.1038/s41419-021-03398-0

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