Low-Coverage Whole Genome Sequencing of Cell-Free DNA From Immunosuppressed Cancer Patients Enables Tumor Fraction Determination and Reveals Relevant Copy Number Alterations

Low-Coverage Whole Genome Sequencing of Cell-Free DNA From Immunosuppressed Cancer Patients Enables Tumor Fraction Determination and Reveals Relevant Copy Number Alterations

Cell-free DNA (cfDNA) analysis is a minimally invasive method that can be used to detect genomic abnormalities by directly testing a blood sample. This method is particularly useful for immunosuppressed patients, who are at high risk of complications from tissue biopsy. The cfDNA tumor fraction (TF)...

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Bibliographic Details
Main Authors: Amira Bouzidi, Karim Labreche, Marine Baron, Marianne Veyri, Jérôme Alexandre Denis, Mehdi Touat, Marc Sanson, Frédéric Davi, Erell Guillerm, Stéphanie Jouannet, Frédéric Charlotte, Franck Bielle, Sylvain Choquet, Pierre-Yves Boëlle, Jacques Cadranel, Véronique Leblond, Brigitte Autran, Jean-Marc Lacorte, Jean-Philippe Spano, Florence Coulet, the IDEATION study group, Ahmed Idbaih, Noureddine Balegroune, Amélie Guihot, Ioannis Theodorou, Agusti Alentorn, Isabelle Brocheriou, Anne-Geneviève, Damien Roos Weil, Alberto Picca
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
liquid biopsy
cfDNA
CNA profile
cancer
immunodeficiency
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.661272/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.661272/full

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