Low-Coverage Whole Genome Sequencing of Cell-Free DNA From Immunosuppressed Cancer Patients Enables Tumor Fraction Determination and Reveals Relevant Copy Number Alterations
Cell-free DNA (cfDNA) analysis is a minimally invasive method that can be used to detect genomic abnormalities by directly testing a blood sample. This method is particularly useful for immunosuppressed patients, who are at high risk of complications from tissue biopsy. The cfDNA tumor fraction (TF)...
Main Authors: | Amira Bouzidi, Karim Labreche, Marine Baron, Marianne Veyri, Jérôme Alexandre Denis, Mehdi Touat, Marc Sanson, Frédéric Davi, Erell Guillerm, Stéphanie Jouannet, Frédéric Charlotte, Franck Bielle, Sylvain Choquet, Pierre-Yves Boëlle, Jacques Cadranel, Véronique Leblond, Brigitte Autran, Jean-Marc Lacorte, Jean-Philippe Spano, Florence Coulet, the IDEATION study group, Ahmed Idbaih, Noureddine Balegroune, Amélie Guihot, Ioannis Theodorou, Agusti Alentorn, Isabelle Brocheriou, Anne-Geneviève, Damien Roos Weil, Alberto Picca |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2021-08-01
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Series: | Frontiers in Cell and Developmental Biology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.661272/full |
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