Treatment with P28GST, a schistosome-derived enzyme, after acute colitis induction in mice: Decrease of intestinal inflammation associated with a down regulation of Th1/Th17 responses.

Treatment with P28GST, a schistosome-derived enzyme, after acute colitis induction in mice: Decrease of intestinal inflammation associated with a down regulation of Th1/Th17 responses.

<h4>Background</h4>P28GST, a 28Kd glutathione S-transferase enzymatic protein derived from a schistosome helminth prevents experimental colitis when administered subcutaneously in the presence of adjuvant by decreasing pro-inflammatory Th1/Th17 response. Given the antioxidant properties...

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Bibliographic Details
Main Authors: Aurore Sarazin, Arnaud Dendooven, Marie Delbeke, Solène Gatault, Aurélien Pagny, Annie Standaert, Christel Rousseaux, Pierre Desreumaux, Laurent Dubuquoy, Monique Capron
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0209681

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https://doi.org/10.1371/journal.pone.0209681

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