Altered synaptobrevin-II trafficking in neurons expressing a synaptophysin mutation associated with a severe neurodevelopmental disorder

Altered synaptobrevin-II trafficking in neurons expressing a synaptophysin mutation associated with a severe neurodevelopmental disorder

Following exocytosis, synaptic vesicles (SVs) have to be reformed with the correct complement of proteins in the correct stoichiometry to ensure continued neurotransmission. Synaptophysin is a highly abundant, integral SV protein necessary for the efficient retrieval of the SV SNARE protein, synapto...

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Bibliographic Details
Main Authors: Callista B. Harper, Grazia M.S. Mancini, Marjon van Slegtenhorst, Michael A. Cousin
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Neurobiology of Disease
Subjects:
Synaptic vesicle
Endocytosis
Neuron
Nerve terminal
Synaptophysin
Synaptobrevin
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996117302103

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http://www.sciencedirect.com/science/article/pii/S0969996117302103

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