Identification of Compounds With Glucocorticoid Sparing Effects on Suppression of Chemokine and Cytokine Production by Rheumatoid Arthritis Fibroblast-Like Synoviocytes

Identification of Compounds With Glucocorticoid Sparing Effects on Suppression of Chemokine and Cytokine Production by Rheumatoid Arthritis Fibroblast-Like Synoviocytes

In recent years target based drug discovery has expanded our therapeutic armamentarium in the treatment of inflammatory and autoimmune diseases. Despite these advances and adverse effects, glucocorticoids remain reliable agents that are used in many of these diseases. The anti-inflammatory mechanism...

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Bibliographic Details
Main Authors: Tadashi Hosoya, Nikunj M. Shukla, Yuya Fujita, Shiyin Yao, Fitzgerald S. Lao, Hiroyuki Baba, Shinsuke Yasuda, Howard B. Cottam, Dennis A. Carson, Tomoko Hayashi, Maripat Corr
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Pharmacology
Subjects:
chemokine
fibroblast
glucocorticoid
high throughput screen
rheumatoid arthritis
synoviocyte
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.607713/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.607713/full

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