Covalent assembly of nanoparticles as a peptidase-degradable platform for molecular MRI

Covalent assembly of nanoparticles as a peptidase-degradable platform for molecular MRI

Iron oxide microparticles (MPIO) are better MRI contrast agents than nanoparticles, but are of limited clinical use as they are not degradable and so risk toxicity. Here the authors present an iron oxide microparticle MRI contrast agent with peptide linkers that enable degradation into non-toxic nan...

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Bibliographic Details
Main Authors: Francisco Perez-Balderas, Sander I. van Kasteren, Alaa A. A. Aljabali, Kim Wals, Sébastien Serres, Andrew Jefferson, Manuel Sarmiento Soto, Alexandre A. Khrapitchev, James R Larkin, Claire Bristow, Seung Seo Lee, Guillaume Bort, Filippo De Simone, Sandra J. Campbell, Robin P. Choudhury, Daniel C. Anthony, Nicola R. Sibson, Benjamin G. Davis
Format: Article
Language:English
Published: Nature Publishing Group 2017-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms14254

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https://doi.org/10.1038/ncomms14254

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