Effects of genetic variation in H3K79 methylation regulatory genes on clinical blood pressure and blood pressure response to hydrochlorothiazide

Effects of genetic variation in H3K79 methylation regulatory genes on clinical blood pressure and blood pressure response to hydrochlorothiazide

<p>Abstract</p> <p>Background</p> <p>Nearly one-third of the United States adult population suffers from hypertension. Hydrochlorothiazide (HCTZ), one of the most commonly used medications to treat hypertension, has variable efficacy. The renal epithelial sodium channel...

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Bibliographic Details
Main Authors: Duarte Julio D, Zineh Issam, Burkley Ben, Gong Yan, Langaee Taimour Y, Turner Stephen T, Chapman Arlene B, Boerwinkle Eric, Gums John G, Cooper-DeHoff Rhonda M, Beitelshees Amber L, Bailey Kent R, Fillingim Roger B, Kone Bruce C, Johnson Julie A
Format: Article
Language:English
Published: BMC 2012-03-01
Series:Journal of Translational Medicine
Subjects:
Pharmacogenomics
Pharmacogenetics
hydrochlorothiazide
hypertension
blood pressure
<it>DOT1L</it>
<it>SIRT1</it>
<it>MLLT3</it>
<it>SGK1</it>
histone methylation
Online Access:http://www.translational-medicine.com/content/10/1/56

Internet

http://www.translational-medicine.com/content/10/1/56

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