Fatal Hypogammaglobulinemia 3 Years after Rituximab in a Patient with Immune Thrombocytopenia: An Underlying Genetic Predisposition?

We report the case of a young woman who developed, 3 years after stopping Rituximab (RTX) prescribed for immune thrombocytopenia (ITP), a severe immunodeficiency leading to fatal pulmonary Epstein–Barr virus-positive diffuse large B-cell lymphoma. Genetic analysis led us to identify four missense mu...

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Bibliographic Details
Main Authors: Jean-François Viallard, Marie Parrens, Frédéric Rieux-Laucat
Format: Article
Language:English
Published: Hindawi Limited 2019-01-01
Series:Case Reports in Immunology
Online Access:http://dx.doi.org/10.1155/2019/2543038