Understanding the Dynamics of Gene Regulatory Systems; Characterisation and Clinical Relevance of cis-Regulatory Polymorphisms

Understanding the Dynamics of Gene Regulatory Systems; Characterisation and Clinical Relevance of cis-Regulatory Polymorphisms

Modern genetic analysis has shown that most polymorphisms associated with human disease are non-coding. Much of the functional information contained in the non-coding genome consists of cis-regulatory sequences (CRSs) that are required to respond to signal transduction cues that direct cell specific...

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Bibliographic Details
Main Authors: Philip Cowie, Ruth Ross, Alasdair MacKenzie
Format: Article
Language:English
Published: MDPI AG 2013-01-01
Series:Biology
Subjects:
gene regulation
cis-regulatory variation
non-coding DNA
chromatin
signal transduction
drug response stratification
cell specificity
context dependency
ENCODE consortium
Online Access:http://www.mdpi.com/2079-7737/2/1/64

Internet

http://www.mdpi.com/2079-7737/2/1/64

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