Abilities of candesartan and other AT receptor blockers to impair angiotensin II-induced AT receptor activation after wash-out
Angiotensin II (Ang II) binds to Ang II type 1 (AT 1 ) receptor and evokes cell signaling, and subsequently stimulates vasoconstriction and cell proliferation, which eventually lead to cardiovascular disease. Since most AT 1 receptor blockers (ARBs) have molecular (differential) effects, we evaluate...
Main Authors: | Yoshihiro Kiya, Shin-ichiro Miura, Yoshino Matsuo, Sadashiva S Karnik, Keijiro Saku |
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Format: | Article |
Language: | English |
Published: |
Hindawi - SAGE Publishing
2012-03-01
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Series: | Journal of the Renin-Angiotensin-Aldosterone System |
Online Access: | https://doi.org/10.1177/1470320311417478 |
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