TGF-β1-Dependent Downregulation of HDAC9 Inhibits Maturation of Human Osteoblasts

Transforming growth factor β (TGF-β) is a key regulator of bone density. Recently, we have shown that TGF-β1 effectively blocks bone morphogenetic protein-induced maturation of human osteoblasts (hOBs) in a histone deacetylase (HDAC)-dependent manner. To better understand the underlying mechanisms a...

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Bibliographic Details
Main Authors: Sabrina Ehnert, Elisabeth Heuberger, Caren Linnemann, Andreas K. Nussler, Stefan Pscherer
Format: Article
Language:English
Published: MDPI AG 2017-11-01
Series:Journal of Functional Morphology and Kinesiology
Subjects:
Online Access:https://www.mdpi.com/2411-5142/2/4/41