The acyl-CoA thioesterase I is regulated by PPARα and HNF4α via a distal response element in the promoter

The acyl-CoA thioesterase I is regulated by PPARα and HNF4α via a distal response element in the promoter

The cytosolic acyl-coenzyme A thioesterase I (Acot1) is an enzyme that hydrolyzes long-chain acyl-CoAs of C12-C20-CoA in chain length to the free fatty acid and CoA. Acot1 was shown previously to be strongly upregulated at the mRNA and protein level in rodents by fibrates. In this study, we show tha...

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Bibliographic Details
Main Authors: Bikesh Dongol, Yatrik Shah, Insook Kim, Frank J. Gonzalez, Mary C. Hunt
Format: Article
Language:English
Published: Elsevier 2007-08-01
Series:Journal of Lipid Research
Subjects:
peroxisome proliferator response element
peroxisome proliferator-activated receptor α
direct repeat 1
acyl-coenzyme A
lipid metabolism
hepatic nuclear factor 4α
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520425143

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http://www.sciencedirect.com/science/article/pii/S0022227520425143

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